Zebrafish through the looking glass: an in vivo glimpse at cardiovascular development and pathology


BCRT Lecture Series 2015

"Linked in regeneration" wants to join young and senior scientists from Berlin to come together and discuss with internationally renowned guest speakers how to advance research into regenerative medicine and its translation into the clinics. The BCRT Lecture Series 2015 is organized and hosted by young postdocs of the graduate school of the BCRT and will take place on Wednesdays once a month at 4.30pm.     

BCRT Lecture Series 2015
Wednesday, 02 Sep 2015 | 4.30 pm



Speaker: Salim Seyfried
(University of Potsdam, Germany)
Host: Doreen Janke (BSRT Postdoc)

Venue:
Auditorium 0.0045
Berlin-Brandenburg Center for Regenerative Therapies (BCRT)
Charité | Campus Virchow Klinikum
Föhrer Str. 15 | 13353 Berlin

Zebrafish through the looking glass: an in vivo glimpse at cardiovascular development and pathology

Research in Prof. Seyfried’s laboratory is primarily focused on signaling events that instruct the assembly of the early heart tube. He uses the embryonic zebrafish heart as model organism to uncover signals that regulate the morphogenesis of myocardium and endocardium. He furthermore investigates to what extent both tissues communicate during cardiac jogging or looping morphogenesis and what determines the differentiation of the endocardium into its different morphological derivatives. By combining detailed expression analyses with functional studies, high-resolution live imaging, and mathematical modeling, his research team tries to elucidate the cellular basis of normal developmental angiogenic and morphological processes within the endocardium.


Three interesting publications

Regulation of β1 Integrin-Klf2-mediated angiogenesis by CCM proteins
[Click here for PubMed]

Blood flow and Bmp signaling control endocardial chamber morphogenesis
[Click here for PubMed]

Unilateral dampening of BMP activity by nodal generates cardiac left-right asymmetry
[Click here for PubMed]








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