Molecular Control of Mature B-Cell Development 5 October 2015 (Ulf Klein)
Molecular Control of Mature B-Cell Developmen
Date: 5th October 2015
Venue: Auditorium 0.0045 | Berlin-Brandenburg Center for Regenerative Therapies (BCRT) Charité | Campus Virchow Klinikum Föhrer Str. 15 | 13353 Berlin
Speaker: Ulf Klein (Columbia University, New York City, USA)
The laboratory's research interests are focused on the elucidation of the molecular mechanisms that govern the differentiation of GC B cells into memory or plasma cells, and on the investigation as to how those mechanisms are disrupted in B-cell malignancies. Since genomic lesions in B cells can lead to the deregulated expression of developmentally important transcription factors - thereby disturbing the control of cellular processes such as proliferation, apoptosis or differentiation -, these studies are expected to provide insights into the oncogenic transformation of mature B-cell lymphomas and leukemias and thereby give clues to establish effective treatment regiments against these malignancies.