Doing it the translational way: Edwin M. Horwitz comments a BCRT-research project


As much as the outcome it is the approach of the study conducted at BCRT which impresses Edwin M. Horwitz. Simon Reinke, Sven Geißler and colleagues of the BCRT investigated what impedes bone regeneration and fracture healing (cf: Sci. Transl. Med. 5, 177ra36 (2013)). In his corresponding article* in Science Translational Medicine, Horwitz points out that the researchers followed an exemplarily conducted bench-to-bedside approach, thus showing the close interaction between regenerative medicine research and translational practices. Furthermore, Horwitz remarks, they highlighted the key role the immune system plays in this context. Keeping in mind the three important principles of regenerative medicine - study of patients, basic scientific research, the intimate association of the immune system with regenerative medicine - Reinke et al. found out that specific immune cells in the blood inhibit the reparative process of a healing fracture. Having gone from bench to bedside and back to the bench again, they showed that following a translational approach positively advanced their study. The researchers started with a thorough investigation of the immune system, then went on to gather data from the patients to go back to the laboratory once more for more elaborate studies based on the collected material. Thus, Horwitz concludes, "[...]The work of Reinke et al. is a shining example of how translational bio-medical research can advance the practice of medicine."

*E. M. Horwitz, Advancing regenerative medicine the translational way. Sci. Transl. Med. 5, 177fs9 (2013).








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