Development of Biomarkers and Regenerative Therapies

We develop immune monitoring for regenerative therapies (Biomarker development and validation). Furthermore, we do research on immune modulation by stem and progenitor cells in vitro and in vivo. We analyze the interaction between the human immune system and biomaterials in vitro and in vivo.

Research Focus

  1. Modulation of inflammatory reactions by stem cells, in particular by mesenchymal stromal cells (MSC)
  2. Delivery of immunological methods and biomarkers for regenerative therapies



  • Biomarker studies in phase I/II-studies with MSC
  • PoC in rat-model (marginal organs)
  • Mechanisms of immunological MSC-effects
  • Immunology of EPC
  • Immunogenicity of spinal disc cells
  • Interaction Immune system and Biomaterials
  • Biomarker-Portfolio for different approaches


(LTR, first row) Michael Schmueck, Annika Fischer, Carolin Giannini (LTR, second row) Hans-Dieter Volk, Amelia Roesel, Sareh Sarmadi, Kerstin Juelke, Cornelia Heckmann (LTR, third raw) Christine Wachlin, Sybill Thomas, Hong Lei


Charité - Universitätsmedizin Berlin
Berlin-Brandenburg Center for
Regenerative Therapies
Institute of Medical Immunology
Augustenburger Platz 1
13353 Berlin

Phone: +49 (0)30 450 524 062
Fax: +49 (0)30 450 524 932